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Growth Hormone Research

Follistatin 344 and ACE-031: Myostatin Inhibitor Research Peptides

By Vault Peptides 2 min read

Myostatin inhibition represents a significant area of muscle biology research, and two peptides — Follistatin 344 and ACE-031 — provide researchers with distinct tools for investigating this pathway.

Follistatin 344

Follistatin is an endogenous glycoprotein that binds and neutralizes members of the TGF-beta superfamily, including myostatin and activin. The 344-amino acid isoform is the most commonly used research variant. Studies have investigated follistatin’s effects on skeletal muscle mass, satellite cell proliferation, and muscle regeneration in preclinical models.

ACE-031

ACE-031 is a soluble form of the activin receptor type IIB (ActRIIB) that acts as a ligand trap for myostatin and related TGF-beta family members. In research, ACE-031 has been studied for its effects on muscle mass, bone density markers, and adipose tissue in various model systems.

Research Considerations

While both peptides target the myostatin pathway, their mechanisms differ. Follistatin directly binds myostatin, while ACE-031 sequesters multiple TGF-beta ligands through receptor competition. This distinction is important for researchers designing pathway-specific studies.

Availability

Both available in 1mg research concentrations from Vault Peptides. Analytical documentation is published where available.

Disclaimer: All products referenced in this article are intended for laboratory and research use only. They are not intended for human consumption. By purchasing from Vault Peptides, you acknowledge these products are for research purposes only and agree to comply with all applicable laws and regulations. Vault Peptides does not make any claims regarding efficacy or safety for non-research applications.

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Research compounds referenced

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For laboratory and research use only (RUO). Not for human or veterinary use, ingestion, or therapeutic application. These statements have not been evaluated by the FDA. No product is intended to diagnose, treat, cure, or prevent any disease.

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